Drugs Choices by Comorbidity (Summary)🩺 Must read.

Condition	Preferred Drugs	Avoid / Contraindicated	Comments
Pregnancy / Pre-eclampsia	Labetalol, Methyldopa, Nifedipine ER, Hydralazine (IV)	ACEi, ARB, Aliskiren, Diuretics (if not required)	Labetalol = first-line
Chronic Kidney Disease (CKD)	ACEi / ARB ± Loop diuretic; Add CCB	NSAIDs, Aliskiren (with ACEi/ARB), high-dose K⁺ sparing	Monitor creatinine and potassium
Asthma / COPD	ARB, ACEi, CCB, Alpha-blocker	Non-selective beta-blockers	Bisoprolol/Nebivolol may be cautiously used
Chronic Liver Disease (CLD)	ACEi/ARB (low dose), Amlodipine	Methyldopa (hepatotoxicity), Minoxidil (fluid retention)	Dose titrate carefully
Heart Failure (HFrEF)	ACEi/ARB/ARNI + Beta-blocker (Bisoprolol, Carvedilol, Metoprolol) + MRA	Non-DHP CCB (Verapamil, Diltiazem)	Use loop diuretics for congestion
Diabetes Mellitus	ACEi/ARB + CCB or Thiazide	Beta-blockers (mask hypoglycemia) if no cardiac indication	Prefer ACEi/ARB to protect kidneys
Post-MI / CAD	Beta-blocker + ACEi/ARB	Dihydropyridine CCB (alone)	Add statin and antiplatelet as indicated

📌 Quick Reference to remember Drugs Safe in Pregnancy.

Drug	Use
Labetalol	First-line oral agent
Methyldopa	Long safety record
Nifedipine (ER)	Safe and effective
Hydralazine (IV)	For hypertensive emergencies

Drugs Choice by Comorbidity. You Must know